Growth Hormone & IGF Research

About Growth Hormone & IGF Research at GenoPept

Everything here touches one cascade: GHRH and ghrelin trigger pituitary growth hormone release, growth hormone drives IGF-1 production, and IGF-1 regulates cell growth. Alongside runs the myostatin brake on muscle, where GDF-8 signals through ActRIIB and is neutralised by follistatin or decoys such as ACE-031.

Preclinical research uses them to study GH pulsatility, receptor pharmacology, IGF-1 signalling in muscle and bone cell lines, and myostatin regulation. Customers include UK universities, contract research organisations and independent researchers.

Compounds in this range

Recombinant growth hormone

• Somatropin HGH 191-AA Research Kit (with Bacteriostatic Water) – 191-amino-acid recombinant human growth hormone with bacteriostatic water; the reference GH receptor ligand (60 IU to 360 IU kits of 10 vials).

GHRH analogues

• Sermorelin (GRF 1-29) – 29-amino-acid GHRH(1-29) analogue for pulsatile GH studies (2mg, 5mg, 10mg, 15mg).
• Tesamorelin – 44-amino-acid stabilised GHRH analogue studied in visceral adipose models (2mg, 5mg, 10mg, 20mg).
• CJC-1295 No DAC (Modified GRF 1-29) – degradation-resistant tetrasubstituted GRF(1-29) for short-acting work (2mg, 5mg, 10mg).
• CJC-1295 with DAC – the same analogue with an albumin-binding Drug Affinity Complex for sustained exposure (2mg, 5mg, 10mg).
• CJC-1295 + Ipamorelin Blend – equal-parts CJC-1295 No DAC and ipamorelin for GHRH plus ghrelin co-activation (10mg, 20mg).

Ghrelin receptor agonists (GH secretagogues)

• Ipamorelin – selective pentapeptide GHSR-1a agonist; studied for GH release with minimal cortisol response (2mg, 5mg, 10mg).
• GHRP-2 (Pralmorelin) – hexapeptide GHSR-1a agonist (pralmorelin), a potent reference secretagogue (5mg, 10mg, 15mg).
• GHRP-6 (Growth Hormone Releasing Peptide-6) – the original hexapeptide GHSR-1a agonist; studied for appetite signalling (5mg, 10mg).
• Hexarelin (Examorelin) – hexapeptide GHSR-1a agonist; studied for cardiac receptor binding (2mg, 5mg).

IGF-1 analogues and mechano growth factor

• IGF-1 LR3 (Long R3 IGF-1) – 83-amino-acid IGF-1 analogue with reduced binding-protein affinity for receptor signalling studies (0.1mg, 1mg).
• IGF-1 DES(1-3) 2mg – 67-amino-acid truncated IGF-1; studied for potency where binding proteins are present (2mg).
• MGF (Mechano Growth Factor) 2mg – 24-amino-acid IGF-1Ec E-peptide; studied for satellite-cell activation after mechanical load (2mg).
• PEG-MGF (Pegylated Mechano Growth Factor) 2mg – PEGylated MGF with extended stability for the same models (2mg).

Myostatin and activin axis

• GDF-8 (Myostatin) 1mg – recombinant mature myostatin homodimer, the native ActRIIB ligand (1mg).
• Follistatin-344 (FST-344) 1mg – recombinant FST-344; the endogenous activin- and myostatin-binding antagonist (1mg).
• ACE-031 1mg – ActRIIB-Fc fusion protein (ramatercept); a decoy receptor sequestering myostatin and activins (1mg).

Choosing between GH and IGF compounds for research

Start from the level of the axis your question sits at. GHRH analogues and GHRPs act upstream and need a somatotroph model. Somatropin acts directly on the GH receptor. IGF-1 analogues and MGF act downstream and suit muscle or bone cell culture, while GDF-8, follistatin and ACE-031 address the ActRIIB pathway.

Among secretagogues, ipamorelin is chosen for selectivity, GHRP-2 for potency, and GHRP-6 or hexarelin for a broader ghrelin-like profile. Between GHRH analogues the choice is usually half-life: sermorelin or CJC-1295 No DAC for pulsatile studies, CJC-1295 with DAC or tesamorelin for sustained exposure.

Purity, testing and Certificates of Analysis

Every batch GenoPept supplies is tested by Puralytix, an independent ISO/IEC 17025 laboratory, using HPLC for purity and LC-MS for identity, and released at 99% purity or higher. Each lot has a Certificate of Analysis showing purity and observed mass, opened from the View Certificate of Analysis button on the product page or the COA library. How to read a COA explains each field.

Ordering research peptides in the UK

Peptides come in 2mg to 20mg vials, proteins 0.1mg to 2mg, somatropin as 60 to 360 IU kits. Bulk boxes of 10 vials save 20 to 50%. Orders ship by tracked Royal Mail Special Delivery (£10), free on orders of £200 or more, with automatic basket discounts of 5% at £300, 10% at £500 and 15% at £1,000. Some lines ship on backorder, around 20 days from verified payment. Payment is by bank transfer or crypto; retail shipping is UK-only, wholesale export by quote. Before starting, read how to reconstitute research peptides, how to store research peptides, the UK legal position on research peptides.

Growth Hormone & IGF Research FAQs

What is the Growth Hormone and IGF research range?

It covers compounds acting on the growth hormone and IGF axis: recombinant somatropin, GHRH analogues, ghrelin receptor agonists (GHRPs), IGF-1 analogues and mechano growth factor, plus the myostatin, follistatin and ActRIIB proteins regulating muscle growth, used in endocrine and muscle-biology research.

What is the difference between CJC-1295 with DAC and CJC-1295 No DAC?

Both are tetrasubstituted GHRH(1-29) analogues with the same four amino-acid changes. CJC-1295 with DAC adds a Drug Affinity Complex that binds serum albumin for a far longer half-life. CJC-1295 No DAC (Modified GRF 1-29) lacks it and suits studies needing a short, pulsatile GHRH signal.

How does GenoPept verify growth hormone and IGF research compounds?

Every batch is tested by Puralytix, an independent ISO/IEC 17025 laboratory, with HPLC for purity and LC-MS for identity, and released at 99% purity or higher. Each lot, including recombinant proteins such as somatropin, has a Certificate of Analysis on the product page and COA library.

How should GH secretagogues and IGF proteins be stored and reconstituted?

Store lyophilised vials at minus 20 degrees Celsius long term, or 2 to 8 degrees short term, away from light. Reconstitute with bacteriostatic water or sterile diluent added down the vial wall, swirling gently; never shake, as proteins denature easily. Keep reconstituted vials at 2 to 8 degrees.

Are these growth hormone research peptides for human use?

No. Every product in this range is for in-vitro laboratory research only. Somatropin kits, GHRH analogues, GHRPs and IGF proteins are not medicines, not for human or veterinary use, and not for diagnostic or therapeutic purposes. Buyers are responsible for compliance with UK law and institutional ethics.

Research use only. Every product in this range is for in-vitro laboratory research only: not for human or veterinary use, not a medicine, not for diagnostic or therapeutic use. See our research use only policy.