What is DSIP?
DSIP (delta sleep-inducing peptide) is a naturally occurring neuropeptide made up of nine amino acids, with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was first isolated from the cerebral venous blood of rabbits during slow-wave (delta) sleep, which gave the peptide its name. GenoPept supplies DSIP in the UK as a lyophilised powder for laboratory research.
DSIP is studied as a regulatory neuropeptide with a broad reported profile in preclinical models, including sleep architecture, stress response and neuroendocrine signalling. It is one of the more widely referenced peptides in sleep-related neuroscience research.
DSIP research applications
Published preclinical research on DSIP spans several model-based areas, listed here for scientific context only.
- Sleep regulation: studied for reported effects on slow-wave sleep patterns in animal models.
- Stress response: investigated for reported modulation of stress-related hormones.
- Neuroprotection: examined for antioxidant-related effects in cell-culture studies.
- Neuroendocrine signalling: research explores reported influence on hypothalamic-pituitary activity.
Mechanism of action (preclinical)
The precise mechanism of DSIP is not fully defined in the literature. In preclinical studies it is reported to modulate neurotransmitter and neuroendocrine systems, including effects on the hypothalamic-pituitary-adrenal axis and on markers of oxidative stress. Some research reports interactions with GABAergic and glutamatergic signalling in animal models. Because DSIP crosses experimental membranes readily, it is used as a probe of central regulatory pathways. These are laboratory observations, not statements about effects in people.
DSIP product specifications
| Compound | DSIP |
|---|---|
| Also known as | Delta sleep-inducing peptide, emideltide |
| Sequence / class | Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) |
| CAS number | 62568-57-4 |
| Molecular formula | C35H48N10O15 |
| Molecular weight | 848.82 g/mol |
| Form | Lyophilised powder |
| Available sizes | 2 mg, 5 mg, 10 mg, 15 mg |
| Purity | Batch-specific; see applicable report |
| Verification | Batch-specific; see applicable report |
| Storage (unopened) | –20 °C long term, protected from light |
| Intended use | In-vitro laboratory research only |
Available sizes
- DSIP 2mg vial
- DSIP 5mg vial
- DSIP 10mg vial
- DSIP 15mg vial
DSIP is offered in the vial sizes listed above for UK research laboratories. Wholesale boxes of 10 vials are available through GenoPept for teams running larger studies, with tiered savings on bulk orders. See the bulk and wholesale page for details.
Reconstitution, handling and storage (laboratory)
DSIP is supplied as a lyophilised (freeze-dried) powder in a sealed sterile glass vial with a black cap. For laboratory reconstitution, add bacteriostatic water or a suitable sterile diluent slowly down the inner vial wall, then swirl gently until dissolved. Never shake the vial, as agitation can shear the peptide.
Store unopened vials at –20 °C for long-term stability, or at 2–8 °C for short periods, protected from light. After reconstitution, keep the solution at 2–8 °C and use it within the window stated in the laboratory protocol. See the GenoPept guides on how to reconstitute research peptides and how to store research peptides.
Quality assurance and Certificate of Analysis
Purity and identity results are batch-specific. Consult the applicable supplied report for its results and methods; confirm the batch covers current stock and verify the laboratory’s accreditation scope directly.
The matching Certificate of Analysis (COA) is available from the “View Certificate of Analysis” button on this page, and the full library is published at the GenoPept COA certificates page. Learn more about what a Certificate of Analysis shows and the UK legal status of research peptides.
Related research compounds
- Pinealon — a neuroprotective tripeptide bioregulator for the nervous system.
- Semax — a nootropic ACTH(4-10) research peptide.
- Selank — a tuftsin-derived anxiolytic research peptide.
- Epitalon — a pineal tetrapeptide studied in longevity and circadian research.
DSIP frequently asked questions
What is DSIP used for in research?
DSIP is used in laboratory research to study sleep regulation, stress response, neuroprotection and neuroendocrine signalling in cell-culture and animal models. As delta sleep-inducing peptide it is a common probe in sleep neuroscience. It is supplied strictly for in-vitro research and is not intended for human use, diagnosis or therapy of any kind.
How is DSIP supplied and what is its purity?
Purity and identity results are batch-specific. Consult the applicable supplied report for its results and methods; confirm the batch covers current stock and verify the laboratory’s accreditation scope directly.
How should DSIP be stored?
Store unopened DSIP vials at –20 °C for long-term stability, or at 2–8 °C for short periods, always protected from light. After reconstitution with bacteriostatic water or sterile diluent, keep the solution at 2–8 °C and use it within the window stated in the laboratory protocol to preserve peptide stability and identity.
Is DSIP for human use?
No. DSIP from GenoPept is a research chemical supplied for in-vitro laboratory research only. It is not a medicine, not for human or veterinary use, and not intended for diagnostic or therapeutic purposes. All handling should be performed by trained personnel in a controlled laboratory setting in line with UK research guidance.
Where does the name delta sleep-inducing peptide come from?
DSIP was first isolated from the cerebral venous blood of rabbits during slow-wave, or delta, sleep, which is how it earned the name delta sleep-inducing peptide. It is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, studied in sleep and stress research in preclinical models only.
Research use only. This product is supplied for in-vitro laboratory research only. It is not for human or veterinary use, is not a medicine, and is not intended for diagnostic or therapeutic use. Handling should be carried out only by qualified personnel in an appropriate laboratory setting.
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