What is Chonluten?
Chonluten is a synthetic Khavinson tripeptide bioregulator with the sequence Glu-Asp-Gly (EDG), modelled on short peptide fractions isolated from lung tissue. It is one of the most cited members of the bioregulator series in respiratory cell biology and is used as a defined chemical tool for studying bronchial epithelium in vitro.
Chonluten has a molecular weight of approximately 319 g/mol, making it one of the lightest peptides in the family. GenoPept supplies Chonluten UK laboratories as a 20mg lyophilised vial for in-vitro research on airway and lung tissue models. The origin of the series and the naming of each tissue-specific peptide are covered in the GenoPept Khavinson bioregulator guide.
Chonluten research applications
Research on this peptide is confined to preclinical settings, chiefly cell culture and rodent models, with a focus on lung and bronchial tissue. The areas below summarise where the published literature has investigated the EDG sequence.
Bronchial epithelium cultures
Chonluten has been investigated in cultures of human bronchial epithelial cells, where reported outcomes include changes in proliferation, apoptosis-related signalling and antioxidant enzyme expression. This is the best-documented setting for the EDG tripeptide.
Oxidative-stress signalling
Research explores whether Chonluten modulates genes involved in the cellular antioxidant response, including those regulated by transcription factors sensitive to oxidative stress. Such experiments typically use lung-derived cell lines under peroxide or smoke-extract challenge.
Inflammatory pathway models
Preclinical work has examined Chonluten in models of airway inflammation, with endpoints focused on cytokine expression and NF-kB-related signalling in epithelial and immune cells. Findings are hedged and remain at the in-vitro and animal stage.
Respiratory tissue ageing
Alongside Bronchogen, Chonluten is included in panels investigating the age-related decline in bronchial epithelial renewal in aged rodents and in long-term organotypic cultures.
Mechanism of action (preclinical)
Chonluten is thought to act through the same nucleus-directed mechanism proposed for other Khavinson peptides. The Glu-Asp-Gly sequence is small and acidic, and published models suggest it can enter cells, bind to promoter regions of target genes and influence chromatin state. In bronchial epithelial cells, research has reported altered expression of genes tied to antioxidant defence, cell proliferation and inflammatory signalling. Some studies describe effects on molecules in the NF-kB pathway, but these observations come from cell-culture experiments and do not establish a defined receptor for Chonluten.
Chonluten product specifications
| Specification | Detail |
|---|---|
| Compound | Chonluten |
| Also known as | Chonluten peptide, EDG peptide, Glu-Asp-Gly, lung bioregulator |
| Sequence / class | 3-amino-acid synthetic tripeptide (Glu-Asp-Gly, EDG) |
| Molecular formula | C11H17N3O8 |
| Molecular weight | 319.3 g/mol (calculated from sequence) |
| Form | Lyophilised powder, sealed sterile glass vial, black cap |
| Available sizes | 20mg vial |
| Purity | Batch-specific; see applicable report |
| Verification | Batch-specific; see applicable report |
| Storage (unopened) | –20 °C long term; 2–8 °C short term, protect from light |
| Intended use | In-vitro laboratory research only |
Available sizes
- 20mg vial (lyophilised powder)
One size is available to UK laboratories. For multi-vial studies, bulk boxes of 10 save 20–50% and wholesale enquiries are handled via our bulk and wholesale page.
Reconstitution, handling and storage (laboratory)
Chonluten is supplied as a lyophilised powder and should be reconstituted only under laboratory conditions. Use bacteriostatic water or a sterile diluent appropriate to your assay. Add the solvent slowly down the inside wall of the vial, swirl gently until the powder dissolves and never shake, as agitation can degrade short peptides. Detailed steps are in our guide to reconstituting research peptides.
Unopened vials should be stored at –20 °C for long-term use, or at 2–8 °C for short periods, protected from light. After reconstitution, keep the solution at 2–8 °C and use it within the period stated in your laboratory protocol. See how to store research peptides for a full summary. Wear gloves and eye protection, work in a clean environment and dispose of residues according to local laboratory rules.
Quality assurance and Certificate of Analysis
Purity and identity results are batch-specific. Consult the applicable supplied report for its results and methods; confirm the batch covers current stock and verify the laboratory’s accreditation scope directly.
Related research compounds
- Bronchogen 20mg – the bronchial tetrapeptide (Ala-Glu-Asp-Leu) most often studied alongside Chonluten
- Crystagen 20mg – the immune tripeptide used when adding an immunological arm to respiratory studies
- Cortagen 20mg – the cortical tetrapeptide, a comparator for tissue selectivity outside the lung
- KPV Anti-Inflammatory Peptide – a tripeptide studied in inflammatory signalling models that complements Chonluten work
Chonluten frequently asked questions
What is Chonluten used for in research?
Chonluten is used in laboratory studies of lung and bronchial epithelial cells. Researchers apply the Glu-Asp-Gly tripeptide to cultured airway cells and rodent models to examine proliferation, antioxidant gene expression and inflammatory signalling. GenoPept supplies Chonluten solely for in-vitro research; it is not a treatment for any condition.
What purity and format does GenoPept Chonluten have?
Purity and identity results are batch-specific. Consult the applicable supplied report for its results and methods; confirm the batch covers current stock and verify the laboratory’s accreditation scope directly.
What are the storage conditions for Chonluten?
Unopened Chonluten vials should be kept at minus 20 degrees Celsius long term, or refrigerated at 2 to 8 degrees Celsius for short-term storage away from light. After reconstitution, refrigerate at 2 to 8 degrees Celsius and use within the period your protocol specifies. Do not shake reconstituted solutions.
Is Chonluten suitable for human consumption?
No. Chonluten is a research chemical for in-vitro laboratory use only. It is not a medicine, is not approved for human or veterinary use and must not be used for diagnostic or therapeutic purposes. GenoPept provides no dosing guidance and sells only for legitimate research in the UK.
Chonluten or Bronchogen for airway research?
Chonluten (Glu-Asp-Gly) was modelled on whole-lung peptide fractions and is the more widely cited of the two in bronchial epithelial cell studies, particularly for antioxidant and inflammatory signalling endpoints. Bronchogen (Ala-Glu-Asp-Leu) is associated with the bronchial mucosa. Many laboratories study both to compare sequence-dependent effects.
Research use only. Chonluten is supplied strictly for in-vitro laboratory research. Not for human or veterinary use, not a medicine, and not for diagnostic or therapeutic use. Full terms: research use only and UK legal status of research peptides.
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