What is Ovagen?
Ovagen is a synthetic tripeptide bioregulator with the sequence Glu-Asp-Leu (EDL), developed as a chemically defined analogue of short peptides found in liver and digestive tissue. It is part of the Khavinson bioregulator family and is studied in models of hepatocyte function, gastrointestinal epithelium and digestive-system ageing.
The leucine residue gives Ovagen a more hydrophobic character than its acidic relatives, which is of interest in membrane-permeability studies. GenoPept supplies Ovagen UK researchers as a 20mg lyophilised vial for in-vitro work. For background on the whole family, read our guide to Khavinson peptide bioregulators.
Ovagen research applications
Research on this peptide is confined to preclinical settings, chiefly cell culture and rodent models, with a focus on liver and gastrointestinal tissue. The areas below summarise where the published literature has investigated the EDL sequence.
Hepatocyte and intestinal epithelial culture
Ovagen has been investigated in liver-derived and intestinal cell lines, with reported outcomes including proliferation, expression of differentiation markers and enzyme activity relevant to digestion and detoxification.
Digestive-system ageing
Research explores whether the EDL tripeptide alters age-related decline in gastrointestinal epithelial renewal and hepatic enzyme expression in aged rodents.
Oxidative-stress protection models
Preclinical studies examine Ovagen in hepatocyte cultures challenged with oxidants or toxins, using antioxidant enzyme expression and apoptosis markers as readouts.
Sequence-comparison experiments
Ovagen is used alongside Livagen (Lys-Glu-Asp-Ala) and Chonluten (Glu-Asp-Gly) to test how the C-terminal residue influences tissue selectivity across the Glu-Asp core shared by many bioregulators.
Mechanism of action (preclinical)
Ovagen is proposed to act through nuclear gene regulation, the mechanism attributed to ultra-short Khavinson peptides. The Glu-Asp-Leu sequence is thought to enter cells, localise to the nucleus and interact with DNA or histone proteins to alter the transcription of genes involved in hepatocyte and intestinal cell renewal. Published in-vitro research reports increased proliferation markers and altered expression of metabolic enzymes in liver-derived cells. These findings are preclinical and a specific binding target for Ovagen has not been established.
Ovagen product specifications
| Specification | Detail |
|---|---|
| Compound | Ovagen |
| Also known as | Ovagen peptide, EDL peptide, Glu-Asp-Leu, liver and digestive bioregulator |
| Sequence / class | 3-amino-acid synthetic tripeptide (Glu-Asp-Leu, EDL) |
| Molecular formula | C15H25N3O8 |
| Molecular weight | 375.4 g/mol (calculated from sequence) |
| Form | Lyophilised powder, sealed sterile glass vial, black cap |
| Available sizes | 20mg vial |
| Purity | ≥99% (HPLC) |
| Verification | HPLC purity and LC-MS identity by independent ISO/IEC 17025 laboratory (Puralytix), batch COA |
| Storage (unopened) | –20 °C long term; 2–8 °C short term, protect from light |
| Intended use | In-vitro laboratory research only |
Available sizes
- 20mg vial (lyophilised powder)
This bioregulator is stocked in the UK in a single vial size. Laboratories running larger studies can order bulk boxes of 10 vials at 20–50% off through our bulk and wholesale page.
Reconstitution, handling and storage (laboratory)
Ovagen is supplied as a lyophilised powder and should be reconstituted only under laboratory conditions. Use bacteriostatic water or a sterile diluent appropriate to your assay. Add the solvent slowly down the inside wall of the vial, swirl gently until the powder dissolves and never shake, as agitation can degrade short peptides. Detailed steps are in our guide to reconstituting research peptides.
Unopened vials should be stored at –20 °C for long-term use, or at 2–8 °C for short periods, protected from light. After reconstitution, keep the solution at 2–8 °C and use it within the period stated in your laboratory protocol. See how to store research peptides for a full summary. Wear gloves and eye protection, work in a clean environment and dispose of residues according to local laboratory rules.
Quality assurance and Certificate of Analysis
Every batch of Ovagen we supply is tested by Puralytix, an independent ISO/IEC 17025 laboratory, using HPLC to confirm purity of at least 99% and LC-MS to confirm identity against the expected mass of the Glu-Asp-Leu sequence. The batch Certificate of Analysis is available through the View Certificate of Analysis button on this page and in our COA library. Our explainer on what a Certificate of Analysis shows describes how to read the chromatogram and mass spectrum.
Related research compounds
- Livagen 20mg – the liver-associated tetrapeptide (Lys-Glu-Asp-Ala) most often compared with Ovagen
- Pancragen 20mg – the pancreatic tetrapeptide for combined digestive-system panels
- Chonluten 20mg – the lung tripeptide sharing the Glu-Asp core, useful in sequence-comparison work
- BPC-157 (Body Protection Compound) – a gastric-derived pentadecapeptide widely studied in gastrointestinal models
Ovagen frequently asked questions
What is Ovagen studied for?
Ovagen is studied in laboratory models of liver and gastrointestinal tissue. Researchers use the Glu-Asp-Leu tripeptide in hepatocyte and intestinal epithelial cultures and in aged rodent models to investigate proliferation, differentiation markers, metabolic enzyme expression and oxidative-stress responses. GenoPept supplies it for in-vitro research use only.
How is Ovagen supplied and what is its purity?
GenoPept Ovagen comes as 20mg of lyophilised powder in a sealed, sterile glass vial with a black cap. Each batch is independently tested by an ISO/IEC 17025 laboratory, with HPLC purity of at least 99% and LC-MS identity confirmation recorded on a Certificate of Analysis you can view before purchase.
What is the correct storage for Ovagen?
Unopened Ovagen should be stored at minus 20 degrees Celsius for long-term stability, or at 2 to 8 degrees Celsius for short periods protected from light. Once reconstituted, keep the solution at 2 to 8 degrees Celsius and use within the period defined by your laboratory protocol.
Can Ovagen be used in humans?
No. Ovagen is supplied strictly for in-vitro laboratory research. It is not a medicine, is not for human or veterinary use and is not for diagnostic or therapeutic purposes. GenoPept provides no dosing or administration information and sells only for legitimate research in the UK.
Is Ovagen a peptide for the ovaries?
No. Despite its name, Ovagen (Glu-Asp-Leu) is associated in the Khavinson literature with liver and digestive tissue rather than ovarian tissue. Reproductive-tissue peptides in the family include Testagen and Prostamax. Researchers interested in hepatic models typically compare Ovagen with Livagen, the lysine-containing liver tetrapeptide.
Research use only. Ovagen is sold for in-vitro laboratory research only. It is not for human or veterinary use, not a medicine, and not for diagnostic or therapeutic use. See our research use only policy and UK legal guidance on research peptides.
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