What is PE-22-28?
PE-22-28 is a synthetic heptapeptide (seven amino acids) with the sequence Gly-Val-Ser-Trp-Gly-Leu-Arg. It is an optimised analogue of spadin, a natural peptide derived from the propeptide region of sortilin. PE-22-28 is studied as a research tool acting on the TREK-1 (two-pore domain) potassium channel. GenoPept supplies PE-22-28 in the UK as a lyophilised powder in a 10 mg vial for laboratory research.
PE-22-28 was engineered to improve potency and stability over the parent spadin fragment, and is reported to block TREK-1 currents with high potency in cell-based assays. It is one of the more studied spadin analogues in ion-channel and neurogenesis research.
PE-22-28 research applications
Preclinical research on PE-22-28 covers several model-based areas, listed here for scientific context only.
- TREK-1 channel research: studied as a potent blocker of TREK-1 potassium currents in cell assays.
- Mood-related models: investigated in animal models relevant to depression research.
- Neurogenesis: research explores reported effects on hippocampal neural progenitor activity.
- Ion-channel pharmacology: used as a probe of two-pore domain potassium channel function.
Mechanism of action (preclinical)
In preclinical studies, PE-22-28 is reported to act as a blocker of the TREK-1 potassium channel, with a reported IC50 in the sub-nanomolar range against human TREK-1 currents. By inhibiting TREK-1, the peptide is reported in animal models to influence serotonergic signalling and hippocampal neurogenesis, which is why it is studied in the context of mood-related research. As an optimised spadin analogue it shows greater potency than the parent peptide in these assays. These are laboratory observations only.
PE-22-28 product specifications
| Compound | PE-22-28 |
|---|---|
| Also known as | Spadin analogue, Gly-Val-Ser-Trp-Gly-Leu-Arg |
| Sequence / class | Synthetic heptapeptide, spadin analogue (Gly-Val-Ser-Trp-Gly-Leu-Arg) |
| CAS number | 1801959-12-5 |
| Molecular formula | C35H55N11O9 |
| Molecular weight | 773.9 g/mol |
| Form | Lyophilised powder |
| Available sizes | 10 mg |
| Purity | Batch-specific; see applicable report |
| Verification | Batch-specific; see applicable report |
| Storage (unopened) | –20 °C long term, protected from light |
| Intended use | In-vitro laboratory research only |
Available sizes
- PE-22-28 10mg vial
PE-22-28 is offered in the vial sizes listed above for UK research laboratories. Wholesale boxes of 10 vials are available through GenoPept for teams running larger studies, with tiered savings on bulk orders. See the bulk and wholesale page for details.
Reconstitution, handling and storage (laboratory)
PE-22-28 is supplied as a lyophilised (freeze-dried) powder in a sealed sterile glass vial with a black cap. For laboratory reconstitution, add bacteriostatic water or a suitable sterile diluent slowly down the inner vial wall, then swirl gently until dissolved. Never shake the vial, as agitation can shear the peptide.
Store unopened vials at –20 °C for long-term stability, or at 2–8 °C for short periods, protected from light. After reconstitution, keep the solution at 2–8 °C and use it within the window stated in the laboratory protocol. See the GenoPept guides on how to reconstitute research peptides and how to store research peptides.
Quality assurance and Certificate of Analysis
Purity and identity results are batch-specific. Consult the applicable supplied report for its results and methods; confirm the batch covers current stock and verify the laboratory’s accreditation scope directly.
The matching Certificate of Analysis (COA) is available from the “View Certificate of Analysis” button on this page, and the full library is published at the GenoPept COA certificates page. Learn more about what a Certificate of Analysis shows and the UK legal status of research peptides.
Related research compounds
- P21 — a CNTF-derived peptide studied in neurogenesis research.
- Semax — a nootropic ACTH(4-10) research peptide.
- Selank — a tuftsin-derived anxiolytic research peptide.
- DSIP — a neuropeptide studied in sleep and stress-response research.
PE-22-28 frequently asked questions
What is PE-22-28 used for in research?
PE-22-28 is used in laboratory research to study the TREK-1 potassium channel, mood-related animal models, hippocampal neurogenesis and ion-channel pharmacology. As an optimised spadin analogue it is examined as a potent TREK-1 blocker in cell assays. It is supplied strictly for in-vitro research and is not intended for human use, diagnosis or therapy.
How is PE-22-28 supplied and what is its purity?
Purity and identity results are batch-specific. Consult the applicable supplied report for its results and methods; confirm the batch covers current stock and verify the laboratory’s accreditation scope directly.
How should PE-22-28 be stored?
Store the unopened PE-22-28 vial at –20 °C for long-term stability, or at 2–8 °C briefly, protected from light. After reconstitution with bacteriostatic water or sterile diluent, keep the solution at 2–8 °C and use it within the window given in the laboratory protocol to preserve peptide integrity.
Is PE-22-28 for human use?
No. PE-22-28 from GenoPept is a research chemical supplied for in-vitro laboratory research only. It is not a medicine, not for human or veterinary use, and not intended for diagnostic or therapeutic purposes. All handling should be carried out by qualified personnel in a controlled laboratory setting in line with UK research guidance.
How is PE-22-28 related to spadin?
PE-22-28 is an optimised analogue of spadin, a natural peptide from the propeptide region of sortilin. It was engineered to be shorter, more potent and more stable than spadin while retaining activity at the TREK-1 potassium channel, which makes it a useful research tool for studying that channel in preclinical models.
Research use only. This product is supplied for in-vitro laboratory research only. It is not for human or veterinary use, is not a medicine, and is not intended for diagnostic or therapeutic use. Handling should be carried out only by qualified personnel in an appropriate laboratory setting.
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