Triptorelin 2mg

What is Triptorelin 2mg?

Triptorelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) in which the glycine at position 6 of the native sequence is replaced with D-tryptophan. This single substitution increases binding affinity for the pituitary GnRH receptor and protects the peptide from rapid enzymatic cleavage, so it has a much longer duration of action than gonadorelin in animal models. GenoPept supplies triptorelin UK laboratories as a 2mg lyophilised research peptide.

The peptide belongs to the same class as the GnRH agonists studied in licensed medicines, and there is extensive published clinical literature on the compound class. As a research reagent, triptorelin is valued because it demonstrates the paradox of GnRH pharmacology: an agonist that stimulates gonadotropin release on first exposure, then suppresses it when exposure is sustained.

Triptorelin 2mg research applications

Triptorelin peptide is used in reproductive endocrinology, receptor-desensitisation and hormone-dependent tissue research. The following areas summarise how it is investigated in laboratory and animal models.

GnRH receptor desensitisation and downregulation

Triptorelin is a standard tool for inducing GnRH receptor desensitisation in pituitary cell culture and animal models. Researchers use it to study the time course of receptor internalisation, loss of gonadotroph responsiveness and recovery after withdrawal.

Hormone-dependent tissue models

Because sustained triptorelin exposure lowers gonadal steroid output in animal models, it is used to create low-oestrogen or low-androgen states for studying steroid-sensitive tissues, including preclinical tumour and endometrial models.

Comparative GnRH analogue pharmacology

Research explores how the D-Trp6 substitution alters receptor affinity, half-life and metabolic stability relative to native GnRH (gonadorelin) and other position-6 analogues, informing structure-activity relationship studies.

Reproductive biology and puberty models

Animal studies investigate triptorelin in models of reproductive-axis suppression and pubertal timing, using LH, FSH and sex-steroid measurements as readouts.

Sustained-release formulation research

Triptorelin is widely used in drug-delivery research as a model peptide for microsphere, implant and depot formulations, where release kinetics are measured in vitro and in animal models.

Mechanism of action (preclinical)

Triptorelin binds the GnRH receptor (GnRHR), a Gq/11-coupled G protein-coupled receptor on pituitary gonadotrophs, activating phospholipase C, calcium mobilisation and protein kinase C. Initial exposure in preclinical models produces a surge of LH and FSH, often termed the flare effect.

With continuous exposure, GnRH receptors are internalised and gonadotroph cells become refractory, so LH and FSH secretion falls and downstream gonadal steroid production declines. The D-tryptophan at position 6 stabilises the peptide’s active conformation and blocks a key protease cleavage site, which is why triptorelin’s receptor occupancy persists far longer than that of gonadorelin.

Triptorelin 2mg product specifications

Available sizes

Triptorelin is currently offered in a single research vial size, which suits most receptor-desensitisation and comparative pharmacology protocols:

• 2mg vial

Laboratories running larger studies can order it in bulk boxes of 10 vials at 20–50% below single-vial pricing through our bulk and wholesale page, with UK-only retail delivery.

Reconstitution, handling and storage (laboratory)

This compound is supplied as a lyophilised powder and should be stored unopened at –20 °C for long-term holding, or at 2–8 °C for short periods, always protected from light. Triptorelin is more resistant to enzymatic degradation than native GnRH, but reconstituted solutions should still be prepared fresh where possible and protected from light.

To reconstitute for in-vitro work, add bacteriostatic water or another sterile diluent slowly down the inside wall of the vial, then swirl gently until the powder dissolves. Never shake the vial, because shear can damage the molecule. After reconstitution keep the solution at 2–8 °C and use it within the period stated in the laboratory protocol. UK laboratories can also read our guides on how to reconstitute research peptides and how to store research peptides.

Quality assurance and Certificate of Analysis

Every batch of Triptorelin sold by GenoPept is tested by an independent third-party laboratory, Puralytix (ISO/IEC 17025 accredited), using HPLC for purity and LC-MS for identity confirmation. The resulting batch Certificate of Analysis (COA) is linked from the “View Certificate of Analysis” button on this page, and the complete library is available at genopept.co.uk/coa-certificates.

The LC-MS identity test confirms the mass expected for the D-Trp6 decapeptide, distinguishing triptorelin from native GnRH and other position-6 analogues, while HPLC quantifies purity. Our article on what a Certificate of Analysis shows explains how to read the purity chromatogram and mass spectrum. Orders are dispatched from the UK by tracked Royal Mail Special Delivery (£10, free on orders over £200), with automatic basket discounts of 5% over £300, 10% over £500 and 15% over £1,000. We accept bank transfer and crypto.

Related research compounds

• Gonadorelin – native-sequence GnRH, the short-acting reference agonist for comparison with triptorelin.
• Kisspeptin-10 – the upstream activator of GnRH neurons for HPG-axis studies.
• HCG (Human Chorionic Gonadotropin) – an LH-receptor agonist used to study gonadal responses downstream of GnRH.
• Oxytocin – another hypothalamic peptide hormone widely used in neuroendocrine research.

Triptorelin 2mg frequently asked questions

What is triptorelin used for in research?

Triptorelin is used to study GnRH receptor desensitisation, gonadotropin suppression and hormone-dependent tissue biology in cell-culture and animal models. It is also a common model peptide in sustained-release formulation research. Its D-Trp6 substitution makes it a useful comparator to native GnRH when investigating how sequence changes alter receptor affinity and duration of action.

How is triptorelin supplied and what purity is it?

GenoPept supplies triptorelin as a 2mg lyophilised powder in a sealed, sterile glass vial with a black cap and batch-identified label. Purity is ≥99%, and every batch is independently tested by Puralytix (ISO/IEC 17025) using HPLC for purity and LC-MS for identity. The batch Certificate of Analysis can be viewed from this product page.

How should triptorelin be stored?

Keep unopened triptorelin vials at –20 °C for long-term storage, or at 2–8 °C short term, protected from light. After reconstitution with bacteriostatic water or sterile diluent, store the solution at 2–8 °C and use it within the period defined by your laboratory protocol. Avoid repeated freeze-thaw cycles and never shake the vial.

Is triptorelin for human use?

No. Triptorelin from GenoPept is supplied strictly for in-vitro laboratory research and is not for human or veterinary use. It is not a medicine and is not intended for diagnostic or therapeutic purposes. GenoPept does not provide dosing, administration or treatment information, and this page is not medical advice.

How does triptorelin differ from gonadorelin?

Gonadorelin is the native GnRH decapeptide with a short half-life in preclinical models, so it is used to study pulsatile stimulation. Triptorelin replaces glycine at position 6 with D-tryptophan, increasing receptor affinity and resistance to enzymatic breakdown; sustained exposure in animal models produces receptor downregulation and gonadotropin suppression. The two compounds therefore serve different experimental purposes within the same receptor system.

Research use only. Triptorelin is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, it is not a medicine, and it is not for diagnostic or therapeutic use. Nothing on this page is medical advice. Read our research use only policy and guide to research peptides and UK law before ordering.