Mazdutide

What is Mazdutide?

Mazdutide is a synthetic 39-amino-acid analogue of oxyntomodulin, a gut hormone that naturally activates both the glucagon-like peptide-1 (GLP-1) receptor and the glucagon receptor (GCGR). Also known by its development codes IBI362 and LY3305677, mazdutide retains this dual-receptor profile while a fatty diacid side chain provides albumin binding and a once-weekly pharmacokinetic profile in published studies.

Mazdutide was developed through a collaboration between two pharmaceutical companies and has been studied extensively in Chinese clinical trials; it is the peptide behind a licensed medicine in China. GenoPept supplies mazdutide as a research peptide for UK laboratories investigating oxyntomodulin-type dual agonism. It is for in-vitro research use only and is not a medicine.

Mazdutide research applications

Mazdutide is used to ask how balanced GLP-1 and glucagon receptor activation affects metabolism. Typical preclinical research areas are outlined below.

Oxyntomodulin receptor pharmacology

Mazdutide is used in cAMP assays on GLP-1 receptor and glucagon receptor-expressing cell lines to quantify relative potency and to compare synthetic analogues with native oxyntomodulin.

Body weight and energy expenditure

In diet-induced obesity models, the peptide has been investigated for effects on food intake, body weight and energy expenditure, with glucagon receptor signalling proposed to add a thermogenic component to GLP-1-mediated appetite suppression.

Hepatic lipid metabolism

Research explores the compound in models of fatty liver and steatohepatitis, measuring hepatic triglyceride content, fatty acid oxidation genes and markers of fibrosis, since glucagon receptor activation directly promotes hepatic lipid catabolism.

Glucose control and islet studies

Mazdutide is studied in rodent glucose tolerance tests and islet preparations to examine whether GLP-1 receptor-driven insulin secretion offsets the glucose-raising action of glucagon receptor agonism.

Mechanism of action (preclinical)

Mazdutide activates the GLP-1 receptor and the glucagon receptor, both class B G-protein-coupled receptors that signal through Gs and cyclic AMP. GLP-1 receptor activation enhances glucose-dependent insulin secretion, slows gastric emptying and reduces food intake through central appetite circuits.

Glucagon receptor activation in the liver increases hepatic fatty acid oxidation and glucose output, and in adipose tissue promotes lipolysis and energy expenditure. In preclinical models the combination is reported to reduce body weight and liver fat more than GLP-1 receptor agonism alone, while the GLP-1 component limits any rise in blood glucose.

Mazdutide product specifications

Available sizes

Mazdutide is available in the following vial sizes:

• 5mg vial
• 10mg vial

Laboratories that need larger quantities can order in bulk boxes of 10 vials, which save 20–50% against single-vial pricing. Retail baskets also receive automatic discounts at £300, £500 and £1,000, and delivery is free on UK orders of £200 or more.

Reconstitution, handling and storage (laboratory)

Unopened Mazdutide vials should be stored at −20 °C for long-term storage, or at 2–8 °C for short periods, and protected from light. Allow the vial to reach room temperature before opening to avoid condensation on the lyophilised cake.

To reconstitute for in-vitro work, add bacteriostatic water or another sterile diluent slowly down the inside wall of the vial, then swirl gently until the powder dissolves. Do not shake, as agitation can damage large acylated peptides. Reconstituted solution should be kept at 2–8 °C and used within the period specified in the laboratory’s own protocol. See our guides on how to reconstitute research peptides and how to store research peptides for step-by-step handling notes.

Quality assurance and Certificate of Analysis

Every batch of Mazdutide is tested by an independent third-party laboratory (Puralytix, ISO/IEC 17025 accredited) using HPLC for purity and LC-MS for identity confirmation. Results are published in a batch-specific Certificate of Analysis (COA), and each vial is labelled with its lot number and expiry date so the paperwork can be matched to the product on the bench.

Use the “View Certificate of Analysis” button on this page to open the current batch COA, or browse the full COA library. Our article on what a Certificate of Analysis shows explains how to read the chromatogram and mass spectrum.

Related research compounds

• Survodutide: a glucagon-based GLP-1/glucagon dual agonist for head-to-head dual-agonist studies.
• Retatrutide: a triple agonist that adds GIP receptor activity to the GLP-1/glucagon profile.
• Semaglutide: the selective GLP-1 receptor agonist reference compound.
• Tirzepatide: a GIP/GLP-1 dual agonist for comparing alternative dual-receptor strategies.

Mazdutide frequently asked questions

What is mazdutide used for in research?

Mazdutide is used in laboratories as a dual GLP-1 and glucagon receptor agonist derived from oxyntomodulin. Preclinical research applies it to receptor signalling assays, diet-induced obesity models, energy expenditure studies, fatty liver models and glucose tolerance experiments. It is supplied for these in-vitro and animal-model research purposes only, never for human or veterinary use.

How is mazdutide supplied and what purity can I expect?

It is supplied as lyophilised powder in a sealed sterile glass vial with a black cap, labelled with lot number and expiry date. Each batch is tested by an independent ISO/IEC 17025 laboratory using HPLC for purity of at least 99% and LC-MS for identity, and the Certificate of Analysis is available from the product page.

How should mazdutide be stored?

Store unopened vials at minus 20 degrees Celsius for long-term storage, or at 2 to 8 degrees Celsius for short periods, protected from light. Once reconstituted with bacteriostatic water or sterile diluent, keep the solution at 2 to 8 degrees Celsius and use it within the period specified in your laboratory protocol.

Is mazdutide from GenoPept for human use?

No. This product is supplied by GenoPept strictly for in-vitro laboratory research. It is not a UK-licensed medicine, is not manufactured for administration, and must not be used for human or veterinary purposes, diagnosis or treatment. Purchasers are responsible for compliance with UK research use only requirements and their institutional policies.

What is the difference between mazdutide and survodutide?

Both are dual GLP-1 and glucagon receptor agonists, but mazdutide is a 39-amino-acid oxyntomodulin analogue whereas survodutide is a 34-amino-acid glucagon-based sequence. They differ in relative receptor potency and molecular weight, and researchers compare them to understand how the peptide scaffold and the GLP-1 to glucagon activity ratio influence metabolic outcomes in preclinical models.

Research use only. Mazdutide is supplied by GenoPept strictly for in-vitro laboratory research. It is not a medicine, is not for human or veterinary use, and is not intended for diagnostic or therapeutic purposes. Read our research use only policy and UK legal guide before ordering.